The Magpies started their ANZAC Day round clash strongly, recording about 40 more possessions in the first quarter.
The skipper Steve Summerton led by example and recorded 14 touches for the term as his side opened up an early 21-point lead.
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Summerton that form to end the match with a massive 39 disposals after a dominant full-game performance.
It wasn't all smooth sailing for the home side, despite controlling the first quarter, with West Adelaide turning the tables in the second to punish costly Magpie errors and capitalise on chances going forward.
The visitors were able to run and carry the ball easily from defence to attack to post a four-goal-to-two second term win thanks to forward Michael Still who caused headaches for the Magpie defenders.
His three-goal effort to half time helped cut Port Adelaide's lead to just nine points.
But the Magpies flew out of the blocks in the third term with four goals in 11 minutes to press its advantage on the scoreboard.
They soon posted a seven-goal term while holding the Bloods to none to all but seal the result at the final break.
The younger players of Angus Bruggemann, Robbie Young, Karl Amon and Zac Hawkins on debut combined with the work-horses of Tom Logan and Steve Summerton, to work the ball forward in the second half and give the Magpie attack ample support.
After a quiet first half, John Butcher booted five goals in the back end of the game to play himself back into form after a disappointing effort on Easter Monday.
Port Adelaide's victory sees them sit second on the ladder after the Panthers notched a win in the concurrent game at Elizabeth.
It will lock in that position if the Eagles defeat Sturt in Sunday's round-closer.
The victory was soured by the late final term injury to Sam Colquhoun who was carried off on a stretcher with a possible knee injury.
More to come.
SCOREBOARD
PORT ADELAIDE 6.1 8.3 15.4 21.8 (134)
WEST ADELAIDE 2.4 6.6 6.9 11.10 (76)
GOALS
Butcher 5, Newton 3, Hitchcock, Moore, Harvey, Mitchell 2, Haren, Bruggemann, Heath, Renouf, Young
portadelaidefc.com.au’s best
Summerton, Logan, Hawkins, Colquhoun, Newton
Injuries?
Colquhoun (TBC)
