Kane Cornes comes into the side fresh from a one-week suspension incurred in Round 16 against Hawthorn, while Cassisi returns from a hamstring injury sustained against Collingwood last month.
The club’s two eldest players will provide experience and class for a critical game against the Lions.
They replace young defender Tom Jonas who will miss the next three weeks with suspension and small forward Jake Neade who has been rested from Sunday’s match.
See the final teams both Port and the Lions here
Sunday's match at AAMI Stadium commences at 12:40pm (ACST), tickets are available at the gate or via Ticketmaster. portadelaidefc.com.au will provide comprehensive coverage of the match including on social media using the #pafclive hashtag
Port Adelaide Round 18 team v Brisbane Lions
FB: Cameron O’Shea, Alipate Carlile, Paul Stewart
HB: Matthew Broadbent, Jackson Trengove, Sam Colquhoun
C: Chad Wingard, Travis Boak, Jasper Pittard
HF: Robbie Gray, John Butcher, Angus Monfries
FF: Justin Westhoff, Jay Schulz, Hamish Hartlett
Foll: Matthew Lobbe, Brad Ebert, Kane Cornes
Interchange: Oliver Wines, Dom Cassisi, Andrew Moore, Kane Mitchell
Emergencies: Matt Thomas, Nathan Blee, Jack Hombsch
In: Dom Cassisi, Kane Cornes
Out: Tom Jonas (suspended), Jake Neade (rested)
