Sam Gray makes way for Monfries in the side after playing three games following his upgrade from the rookie list.
Ken Hinkley said Gray was omitted from the side purely based on the need to select the highly experienced team leader Monfries.
"The main thing is that we've had a high quality player who was always going to come back into the side given he's had a reasonably short layoff," Hinkley told portadelaidefc.com.au.
"Sam's form has been really strong and solid - we've been pleased with what he's been able to do - and we now know we've got another AFL player on our list.
"He understands he's been replaced by a high quality player."
Meanwhile the club will debut Irish youngster Daniel Flynn in the SANFL.
If Krakouer is selected in the final Magpies lineup, it will be his first League game for the clubsince returning to Port Adelaide during the off-season.
The 21-man Magpies team will be confirmed ahead of the match played at the Clare Oval at 2:10pm on Sunday afternoon.
Port Adelaide Round 7 AFL team v GWS Giants
FB: Jack Hombsch, Alipate Carlile, Jarman Impey
HB: Tom Jonas, Jackson Trengove, Jasper Pittard
C: Jared Polec, Travis Boak, Kane Cornes
HF: Dom Cassisi, Justin Westhoff, Hamish Hartlett
FF: Robbie Gray, Jay Schulz, Chad Wingard
Followers: Matthew Lobbe, Ollie Wines, Brad Ebert
Interchange: Matthew Broadbent, Angus Monfries, Matthew White, Aaron Young
Emergencies: Paul Stewart, Ben Newton, Sam Gray
In: Angus Monfries
Out: Sam Gray (omitted)
Milestones: Matthew Lobbe - 50th AFL games
Port Adelaide Round 5 SANFL team v Crows State League Team
FB: Tom Logan, Tom Clurey, Ben Haren
HB: Campbell Heath, Angus Bruggemann, Anthony Biemans
C: Cam O'Shea, Steven Summerton, Paul Stewart
HF: Andrew Moore, John Butcher, Kane Mitchell
FF: Henry Slattery, Mitch Harvey, Sam Gray
Followers: Brent Renouf, Jake Neade, Ben Newton
Interchange: Karl Amon, Nathan Krakouer, Robbie Young, Zac Hawkins, Daniel Flynn
In: Flynn, S. Gray, Slattery, Krakouer, Neade
Out: Colquhoun (knee), Hitchcock (shin), Byrne-Jones (soreness)