The game at Traeger Park has been confirmed for Indigenous Round, which is Round 11. It will be a Melbourne home game.
Port Adelaide has played at Traeger Park twice in the past three years, but in the NAB Cup and NAB Challenge – a narrow loss to Richmond in 2011 and a six-point win over West Coast in 2013.
The Power has been involved in games in the Northern Territory in every season since 2008, as well as playing games there in 2004 and 2006 and has built up a strong supporter base in the Territory.
Port Adelaide CEO Keith Thomas said the club was delighted to be playing in Alice Springs.
"To play the first game for premiership points in Alice Springs is an historical event of great significance and we are excited to be part of it," Thomas said.
"We already have a connection with Alice Springs having played pre-season cup games there in 2011 and 2013 and to be able to continue playing in the Northern Territory really reinforces our central corridor strategy which is very important to us."
The full AFL fixture is set to be released on Thursday 31 October.
